Post-implantation mouse conceptuses produce paracrine signals that regulate the uterine endometrium undergoing decidualization
نویسندگان
چکیده
منابع مشابه
Msx Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium
The mammalian Msx homeobox genes, Msx1 and Msx2, encode transcription factors that control organogenesis and tissue interactions during embryonic development. We observed overlapping expression of these factors in uterine epithelial and stromal compartments of pregnant mice prior to embryo implantation. Conditional ablation of both Msx1 and Msx2 in the uterus resulted in female infertility due ...
متن کاملStudy of human post-implantation conceptuses, normal and abnormal.
Important data relative to organogenesis and teratogenesis can be learned from the study of early embryos derived from induced abortions, which are legal in Japan. Nearly 1/3 of the conceptuses from the unrecognized period of pregnancy (less than 35 days) possess abnormalities, most of which would normally cause them to be aborted. The commonest findings were degeneration and necrosis and neu...
متن کاملFollistatin is critical for mouse uterine receptivity and decidualization.
Embryo implantation remains a significant challenge for assisted reproductive technology, with implantation failure occurring in ∼50% of in vitro fertilization attempts. Understanding the molecular mechanisms underlying uterine receptivity will enable the development of new interventions and biomarkers. TGFβ family signaling in the uterus is critical for establishing and maintaining pregnancy. ...
متن کاملA distinct cohort of the TGFβ superfamily members expressed in human endometrium regulate decidualization
BACKGROUND Successful blastocyst implantation requires the differentiation of human endometrial stromal cells (HESC), a process known as decidualization. Activin A, a transforming growth factor beta (TGFbeta) superfamily member, enhances HESC decidualization and localizes to decidual cells in human endometrium. Other TGFbeta superfamily members, including BMP2, BMP4, BMP7, GDF5, GDF8, GDF11, TG...
متن کاملA distinct cohort of the TGFb superfamily members expressed in human endometrium regulate decidualization
BACKGROUND: Successful blastocyst implantation requires the differentiation of human endometrial stromal cells (HESC), a process known as decidualization. Activin A, a transforming growth factor b (TGFb) superfamily member, enhances HESC decidualization and localizes to decidual cells in human endometrium. Other TGFb superfamily members, including BMP2, BMP4, BMP7, GDF5, GDF8, GDF11, TGFbs and ...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2006
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2006.03.006